Co-Evolutionary Learning for Cognitive Computer Generated Entities

In this paper, an approach is advocated to use a hybrid approach towards learning behaviour for computer generated entities (CGEs) in a serious gaming setting. Hereby, an agent equipped with cognitive model is used but this agent is enhanced with Machine Learning (ML) capabilities. This facilitates the agent to exhibit human like behaviour but avoid an expert having to define all parameters explicitly. More in particular, the ML approach utilizes co-evolution as a learning paradigm. An evaluation in the domain of one-versus-one air combat shows promising results

Heavy quarkonium: progress, puzzles, and opportunities

A golden age for heavy quarkonium physics dawned a decade ago, initiated by the confluence of exciting advances in quantum chromodynamics (QCD) and an explosion of related experimental activity. The early years of this period were chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in 2004, which presented a comprehensive review of the status of the field at that time and provided specific recommendations for further progress. However, the broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles could only be partially anticipated. Since the release of the YR, the BESII program concluded only to give birth to BESIII; the $B$-factories and CLEO-c flourished; quarkonium production and polarization measurements at HERA and the Tevatron matured; and heavy-ion collisions at RHIC have opened a window on the deconfinement regime. All these experiments leave legacies of quality, precision, and unsolved mysteries for quarkonium physics, and therefore beg for continuing investigations. The plethora of newly-found quarkonium-like states unleashed a flood of theoretical investigations into new forms of matter such as quark-gluon hybrids, mesonic molecules, and tetraquarks. Measurements of the spectroscopy, decays, production, and in-medium behavior of c\bar{c}, b\bar{b}, and b\bar{c} bound states have been shown to validate some theoretical approaches to QCD and highlight lack of quantitative success for others. The intriguing details of quarkonium suppression in heavy-ion collisions that have emerged from RHIC have elevated the importance of separating hot- and cold-nuclear-matter effects in quark-gluon plasma studies. This review systematically addresses all these matters and concludes by prioritizing directions for ongoing and future efforts.Comment: 182 pages, 112 figures. Editors: N. Brambilla, S. Eidelman, B. K. Heltsley, R. Vogt. Section Coordinators: G. T. Bodwin, E. Eichten, A. D. Frawley, A. B. Meyer, R. E. Mitchell, V. Papadimitriou, P. Petreczky, A. A. Petrov, P. Robbe, A. Vair

A Measurement of the Proton Structure Function F ⁣2(x,Q2)F_{\!2}(x,Q^2)

A measurement of the proton structure function $F_{\!2}(x,Q^2)$ is reported for momentum transfer squared $Q^2$ between 4.5 $GeV^2$ and 1600 $GeV^2$ and for Bjorken $x$ between $1.8\cdot10^{-4}$ and 0.13 using data collected by the HERA experiment H1 in 1993. It is observed that $F_{\!2}$ increases significantly with decreasing $x$, confirming our previous measurement made with one tenth of the data available in this analysis. The $Q^2$ dependence is approximately logarithmic over the full kinematic range covered. The subsample of deep inelastic events with a large pseudo-rapidity gap in the hadronic energy flow close to the proton remnant is used to measure the "diffractive" contribution to $F_{\!2}$.Comment: 32 pages, ps, appended as compressed, uuencoded fil

Beschichtungen fuer verschleiss- und korrosionsbeanspruchte Bauteile der Kunststoffverarbeitung. Teilvorhaben: Einfluss der Vorbehandlung zu beschichtender Bauteile auf das Verschleissergebnis in Kunststoffverarbeitungsmaschinen Abschlussbericht

Target of investigations was the application of existing / new thin layer systems in plastic processing machines in range of extruding tools with extra high requests with respect to abrasion and corrosion strength. With model wear investigations as well as user relevant practical trials was worked out the influence of the pre-treatment of the application of different coating types on the wear results in plastic processing machines. In the inspected cases application of selected CVD-coated types led to good results. The technical suitability of the developed coating system was proved. (orig.)Available from TIB Hannover: DtF QN1(73,22) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman

LDL-Rezeptor Gentherapie: In vivo imaging des LDL-Rezeptor Gentransfers Schlussbericht

Familial Hypercholesterolemia (FH) is associated with the early onset of coronary sclerosis. Deficiency of the LDL-receptor (LDL-r), which is normally expressed for 70% in the liver, is the underlying defect. For this reason the Familial Hypercholesterolemia is an ideal model, for the evaluation of gene therapy strategies in the liver. The goal of this project was the evaluation of an external in vivo imaging technique to monitor the gene transfer of the LDL-receptor in rabbits. Gene transfer was performed using adenoviral vectors, containing a human CMV promoter and the human LDL-receptor or #beta#-galactosidase as negative control. Before and after gene transfer of the LDL-receptor, the LDL fraction was isolated, radiolabeled with indium and injected in LDL-receptor deficient rabbits (Watanabe Heritable Hyperlipidemic, WHHL, rabbits). Scans were performed at different following time points. Scans before and after gene transfer revealed the specific uptake of human LDL via the human LDL-receptor in WHHL-rabbits. The successful gene transfer was confirmed by estimation of plasma cholesterol levels and in vivo LDL-kinetic studies before and after gene transfer. Specific uptake of LDL in hepatocytes was confirmed by isolation of parenchyma cells and the quantification of radioactivity compared to non-parenchyma cells of the liver. Histological analysis verified the presence of the LDL-receptor in the liver after gene transfer. We evaluated a sensitive external imaging technique, which is useful to monitor the gene transfer and efficiency of gene transfer of the LDL-receptor, and which allows a semi quantitative analysis. This method seems to be more sensitive, as the determination of serum cholesterol levels in this model. This technique may be useful to monitor other cell membran receptor mediated gene transfer experiments. Concerning radioactivity and the used tracer the method can be established in humans. For the first time there might be the oppertunity to obtain an in vivo diagnostic tool to determine the deficiency of the human LDL-receptor. (orig.)SIGLEAvailable from TIB Hannover: DtF QN1(80,50) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung und Forschung (BMBF), Bonn (Germany)DEGerman

Grobstruktur-Simulation turbulenter Stroemungsphaenomene im Hinblick auf destabilisierende Prozesse beim Strahlzerfall in Hochdruck-H_2/O_2-Raketentriebwerken

Internal turbulence of the injector flow and the liquid free jet is identified as the mechanism that induces primary disturbances at the liquid jet surface emerging from the coaxial injector in high pressure H_2/O_2 rocket engines. Large-Eddy-Simulation of the turbulent flow field is applied for various cases of the injector flow. Based on the injector flow, turbulence evolution inside the emerging free jet is simulated by computing the relaxation of turbulence between pseudo walls assuming slip conditions. Presentation of momentary as well as time averaged results gives a physical insight in the spatial and temporal processes of turbulence for several fluids under various boundary conditions. Correlations were found between experimentally observed surface perturbations at the liquid jet surface directly after injector exit and computed length as well as velocity scales of coherent turbulent structures in the liquid core flow inside the injector. (orig.)SIGLEAvailable from TIB Hannover: RN 437(94-28) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Forschungsverbund 'Komplikationen der Organtransplantation durch Herpesviren'. Foerderperiode: 1993-1996 Schlussbericht

In this project application of a very sensitive molecularbiological diagnosis of HCMV-viremia in correlation to the definition of defective reconstitution of antivirial T cell immune responses allowed to early define patients at risk for HCMV disease after BMT and to optimize antiviral therapy with ganciclovir. Thus prognosis of patients with HCMV infection after BMT was significantly improved particularly due to the reduction of early HCMV disease. Specificity of protective T cell immune responses were analyzed in patients with asymptomatic viremia after BMT and shown to be directed against dominant epitopes of the HCMV proteins pp65 and gH in different patients. These immunogenic structures could be used for immunization or ex vivo expansion of antiviral T cells for long term reconstitution of antiviral immunity and protection from late onset HCMV disease. Definition of variants of HCMV showed gB variants type 2-4 as well as frequent point mutations of the immediated early genes to correlate with the development of symptoms of HCMV disease indicating unfavourable influences of the virus on host interactions. (orig.)Available from TIB Hannover: F97B2385 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman